Day 1

Opening Remarks

Stefano Bonini (Italy)

Claes H. Dohlman Conference Address

Shigeru Kinoshita (Japan) – The ocular surface in health and disease

Stefano Bonini (Italy)

1

Sugar Can Be Good For You: Glycobiology & Mucins

Mucins, cornea & conjunctival epithelial cells, goblet cells, nerves, glycosylation, signaling, biochemistry, gene expression, regulation, functions, translational research, etc.

Tom Korfhagen (USA) – Goblet cell differentiation

Michael A. Hollingsworth (USA) - Membrane mucins as multifunctional molecules

Pablo Argueso (USA)

Monica S. Berry (UK)

Anna Guzman-Aranguez (Spain)

2

International Dry Eye WorkShop: Updates

The Dry Eye WorkShop (DEWS) was an international workshop convened to review critically the classification, epidemiology, diagnosis, basic and clinical research, management and therapy, and clinical trial methodology of dry eye disease. The DEWS report, which required the efforts of over 70 people for several years, was published in The Ocular Surface in 2007 and is available in multiple languages at www.TearFilm.org. This session will feature recent advances in all DEWS topics.

Anthony J. Bron (UK) – Recent advances in defining and classifying dry eye disease

Kelly K. Nichols (USA) – Epidemiology

Murat Dogru (Japan) – Methodologies to diagnose and monitor dry eye disease

Gary N. Foulks (USA) – Design and conduct of clinical trials

Michael A. Lemp (USA) – Management and therapy

Ilene K. Gipson (USA) – New research advances in understanding dry eye disease

Donald R. Korb (USA)

Kyung-Sun Na (Korea)


John E. Sutphin (USA)

Poster Session 1

Philipp Ackermann (Germany)

Thomas J. Millar (Australia)

Friedrich P. Paulsen (Germany)

3

Reports from the International Workshop on Meibomian Gland Dysfunction (MGD)

The International Workshop on Meibomian Gland Dysfunction (MGD) was designed to: [a] conduct an evidence-based evaluation of meibomian gland structure and function in health and disease;
[b] develop a contemporary understanding of the definition and classification of MGD;
[c] assess methods of diagnosis, evaluation and grading of severity of MGD;
[d] develop appropriate norms of clinical trial design to evaluate pharmaceutical interventions for the treatment of MGD; and [e] develop recommendations for the management and therapy of MGD. More information about this Workshop, which is currently ongoing, may be found at http://www.tearfilm.org/
mgdworkshop/ This session will feature reports from this Workshop

Kelly K. Nichols (USA) – Introduction

Erich Knop (Germany) – Anatomy, physiology & pathophysiology

Kari Green-Church (USA) – Tear film lipids, and lipid-protein interactions in health and disease

J. Daniel Nelson (USA) – Definition & Classification

Debra A. Schaumberg (USA) – Epidemiology of, and risk factors for, MGD

Alan Tomlinson (UK) – Evaluation, diagnosis & grading of severity of MGD

Penny A. Asbell (USA) – Design & conduct of clinical trials

Gerd Geerling (Germany) – Management & therapy

Colin Cerretani (USA)

James P. McCulley (USA)

Eric B. Papas (Australia)

4

The Tearome: Not Just Hype

Lacrimal and meibomian glands, ocular surface cells, nerves, secretion, signaling, transport, biochemistry, gene expression, control systems, functions, sex differences, osmolarity, and translational research, as well as tear film biophysics, biomechanics, proteomics, lipidomics and glycomics, etc.

Miguel C. Seabra (UK) – Molecular mechanisms of regulated exocytosis

Michal L. Schwartzman (USA) – Eicosanoids

Kazuo Tsubota (Japan) – Impact of aging on the ocular surface

Ben Glasgow (USA)

Gordon Laurie (USA)

James Mun (USA)

Day 2

5

Late Breaking News: Sjögren’s Syndrome

All aspects

Kathy Moser (USA) – Genetics

Barbara Caffery (Canada) – Clinical & biochemical aspects

Denise L. Faustman (USA) – Embryogenesis, autoimmunity & treatment

Simon Bowman (UK) – Quality of life

Troy E. Daniels (USA) - Current status and future objectives of the Sjögren’s International Collaborative Clinical Alliance

Esen K. Akpek (USA)

Ammon B. Peck (USA)

Yuichi Uchino (Japan)

6

Visual & Optical Effects of Tear Film Instability

All aspects of tear film instability

Carolyn Begley (USA) – Impact of tear film instability on visual acuity

Larry N. Thibos (USA) – Optical effects of tear film instability

Pablo Artal (Spain)

Christine Purslow (UK)

Eric Xiaojia Wei (Australia)

Poster Session 2

Fabian Garreis (Germany)

Winston W. Kao (USA)

Eduardo M. Rocha (Brazil)

7

Inflammation: A Cause or Consequence of Ocular Surface Disease

Inflammation, immunity, Toll-like receptors, allergy, etc.

Richard S. Blumberg (USA) - Inflammation: A cause or consequence of mucosal disease.

Reza Dana (USA) - Induction of CD4+ T cell mediated immunity in dry eye disease

Robert L. Hendricks (USA) - Role of inflammation in HSV-1-induced stromal keratitis

Virginia L. Calder (UK)

Laura Contreras Ruiz (Spain)


Alison M. McDermott (USA)

8

The Best Defense is a Good Offense: Ocular Surface Infection

Bacteria, viruses, fungal, keratitis, Acanthamoeba and other infections

Suzanne M. J. Fleiszig (USA) – Bacterial-host interactions at the ocular surface

Eric Pearlman (USA) – Fungal keratitis

Noorjahan Panjwani (USA) – Impact of Acanthamoeba infection on the tear film and ocular surface

Danielle Augustin (USA)

Gerald B. Pier (USA)

Fiona J. Stapleton (Australia)

Day 3

9

Ocular Surface Regeneration & Reconstruction

Stems cells from all ocular surface tissues and adnexa, repair, regeneration

Masataka Ito (Japan) – Lacrimal gland regeneration

Graziella Pellegrini (Italy) – Ocular surface stem cells

Shigeto Shimmura (Japan) – Ocular surface reconstruction

Dimitri T. Azar ( USA)

Victor L. Perez (USA)

Jose Ricardo (Brazil)

10

Drug, Preservative and Contact Lens Solution Interactions with the Tear Film and Ocular Surface

All aspects

Lyndon Jones (Canada) – Contact lens solutions

Christophe Baudouin (France) – Effects of all topical drug preservatives on the tear film and ocular surface

11

Macro to Micro: New Imaging Approaches for Understanding the Ocular Surface

All aspects

Roberto Weigert (USA) - Imaging protein secretion in the exocrine glands of live animals by intravital microscopy

Nathan Efron (Australia) – Ocular surface imaging

Shukti Chakravarti (USA)

Thomas Fuchsluger (USA)

Jianhua Wang (USA)

12

New and Emerging Diagnostics and Treatments

Emerging diagnostic technologies, outcome measures, new therapies, etc

Franz Grus (Germany) – Relevance of tear film proteomics for the diagnosis of disease

Alexander V. Kabanov (USA) – New polymer systems for delivery of therapeutics

James Chodosh (USA) – Keratoprostheses

José Alvaro P Gomes (Brazil)

Stefan Schrader (UK)

Jun Shimazaki (Japan)

Closing Session

Sarah F. Hamm-Alvarez (USA) – Basic research perspective

Jason J. Nichols (USA) – Clinical research perspective

Melissa Liew (USA) - Industry perspective

Carlos Belmonte (Spain)

Closing Remarks

Carlos Belmonte (Spain)